ࡱ> ] Rubjbj8ee| 8$Tx$m8 7777777$:A=J7E7H'8!!!7!7!!*24-n(27=80m826=C,44V=4C$p48!77!m8C :  %{Q0̃NeP^ zYef['Y~ zW,gOo`Course Information  zNxCourse Code SP185*f[eCredit Hours 16*f[RCredits 1* zTyCourse Name -Ne %{Q0̃NeP^e nutrition, microbiota and health z'`((Course Type)euxc[aAudience [,g zatQvhQ!h,gyNt^~uc(Language of Instruction)-Ne*_b|School u}Tyf[Nb/gf[b_uir|HQO zPrerequisite cYe^Instructor uzs^0 _hVf zQ@W(Course Webpage)* z{NDescription NSOvSQqQu@w1000yN Nv_uir vQxvWVpeϑ/fNSOꁫWVpeϑv50-100P ُN_uirN=ve_X[(W [[;NvMQuTN"w@w͑\O(u0vMRvxvzSs NTtvߘ~gSN4xOWS̃ bMQuk }ۏeQ@m _wba'`pu ۏ _Sր0|?\u0Q_uI{Tyba'`u0OncYy'Yĉ!jpenccSTuirOo`ccb/g xvz%{Q0̃NNSOeP^ NvvNq_T /fvMRsQNba'`uxvzvN*N^8^p蕄vevf[yeT0ُ*NeTvz4x gS_SQNS̃:Nvpvuuf0ߘSoirr^eel [ba'`N"'`uuv2TluwQ g͑aIN0,g z\Nc@b(WVASYt^eg(Wf[yeT N@bS_vxvzbg\O:NHhO ۏLmeQEmQ0OfavYef[0 ^gǏُ*N z O'Y[Ƌ0R%{Q0S̃NeP^v[RsQ|RaS0R1uNؚϑKm[b/gvQs uirpenc_Yrp'`vX {:gyf[Nb/g0pef[I{f[y(Wuir;Sf[xvz-Nev͑v0WMOT\O(u0 ^g8T_NRf[usQl{uirf[vSU\ sQl̃NN{|ba'`uvxvz :NW{QYTWvReNMbZPQ!.s0 z-N_NOzcN~NNǏ%{QtSOvwƋTel ^g[Oۏ'Y[veP^w0RN[v\O(u0* z{NDescription Human beings are  superorganisms with more than 1000 different species of bacteria living inside us. Gut microbiota plays a pivotal role in human nutrition, immunity and metabolism. Structurally disrupted gut microbiota may lead to chronic inflammation, a primary pathological condition underlying obesity, diabetes cardiovascular diseases and cancers. Data retrieval via high-throughput molecular profiling methods and data mining via computational biology are two basic tools for understanding the complex relationship between gut microbiota and chronic diseases. This has become a very hot topic in the frontiers of biomedical sciences. Research along this line may lead to gut microbiota-targeted nutritional and medicinal products and will have significant impact on prevention and treatment of chronic diseases.Based on our research experiences during the last decade, this short course will focus on design principle and data mining method for understanding the role of gut microbiota and its interaction with host and diets in development of chronic metabolic diseases. The lectures will use layman language to explain the science behind our published papers. Students will have hands-on experience on data mining methods. After you take this course, you will have a good understanding on the role of gut microbiota in nutrition-related diseases such as obesity and diabetes and a deep appreciation on the impact of computational biology in the future development of biomedical sciences. 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Genomic microdiversity of Bifidobacterium pseudocatenulatum underlying differential strain-level responses to dietary carbohydrate intervention. mBio, 8(1): e02348-02316. Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L. M., Yang, S., Holmes, E., Tang, H., Zhao, G., Nicholson, J. K., Li, L., & Zhao, L. 2008. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A, 105(6): 2117-2122. Zhang, C., Yin, A., Li, H., Wang, R., Wu, G., Shen, J., Zhang, M., Wang, L., Hou, Y., Ouyang, H., Zhang, Y., Zheng, Y., Wang, J., Lv, X., Wang, Y., Zhang, F., Zeng, B., Li, W., Yan, F., Zhao, Y., Pang, X., Zhang, X., Fu, H., Chen, F., Zhao, N., Hamaker, B. R., Bridgewater, L. C., Weinkove, D., Clement, K., Dore, J., Holmes, E., Xiao, H., Zhao, G., Yang, S., Bork, P., Nicholson, J. K., Wei, H., Tang, H., & Zhao, L. 2015. Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine, 2(8): 968-984.vQ[More YlNotes Ylf1&^*Q[:N_kXy02 z{NW[pe:N300-500W[ z'Y~NhnZiYef[[c:N[ W[peNP0fjhjzjjloPtvvfff$ & F$Ifa$gd3 $$Ifa$gdDV}kd4$$Iflr0;#f ^ t0&644 laytDVm,mnoooopVpfprtt.tNtPtRtVtXtdtfthtjtntpt~tttttt޾|umumubumumubu]Uh haTVo( h=o(hDVhT B* phPhDVhT o( hDVhT h3h35B* \phP$h3h]s56B* \]o(phP!h3h]s5>*B* \o(phPh3h]s5B* \o(phPh #5B* \o(phP$h3h356B* \]o(phPh3h35B* \o(phP!h3h35>*B* \o(phPPtRtXtfthtvvv $$Ifa$gdDV}kd$$Ifl:0;#f ^ t0&644 laytDVhtjtptttvvv $$Ifa$gdDV}kdX$$Ifl 0;#f ^ t0&644 laytDVtttttttuuu uuvhhcacacacgd~WdpWD`gd= $8XDda$gdDV}kd$$Ifl 0;#f ^ t0&644 laytDV tttttttttttttuuuuu u uuuuuhWjhWU haTVh hSt hSto(h haTVo( h@o( h haTVuuuudpWD`gd=6182P:p). 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